HEX-EN (Snow)

Buy HEX-EN (SNOW) in Europe

HEX-EN, (also known as NEH and N-Ethylhexedrone) is a very popular novel stimulant substance of the cathinone class. HEX-EN is a derivative of hexedrone. Little is known about its pharmacology, although it likely acts by increasing levels of norepinephrine and dopamine in the brain. The original synthesis date of N-ethylhexedrone is unknown. It appears to have emerged on the online research chemical market in late 2015. It is an example of a novel psychoactive substance specifically chosen to mimic the features of prohibited substances and bypass drug laws.

HEX-EN (SNOW) Animal Studies

In mouse locomotor studies, N-ethylhexedrone resulted in time- and dose-dependent stimulation of locomotor activity following doses of 10 to 50 mg/kg, i.p. The locomotor stimulating effects of 10 and 25 mg/kg occurred within 10 min following injection and lasted 120-240 min. An ED50 of 7.7 mg/kg was calculated for N-ethylhexedrone. In comparison to the locomotor stimulating effects of cocaine and methamphetamine, N-ethylhexedrone produced 108% and 91% of the maximal stimulant effect, respectively.
In rat drug discrimination studies, N-ethylhexedrone fully substituted for the discriminative stimulus effects of 10 mg/kg cocaine, i.p., with an ED50 of 3.42 mg/kg. The response rates were increased to 131% of the vehicle control response rates following a dose of 5 mg/kg N-ethylhexedrone. Similarly, N-ethylhexedrone i.p. fully substituted for the discriminative stimulus effects of 1 mg/kg i.p. fully (+)-methamphetamine i.p., with an ED50 value of 1.44 mg/kg. The response rates after N-ethylhexedrone were not significantly changed from vehicle control response rates at the doses that were tested.